T. Nicholas Jones, Chemistry
Dendrimers—highly branched macromolecules—present an attractive option for use as a catalytic framework because of their large size and their availability for functionalization. In addition, the use of organocatalysts to form asymmetric products has become an increasingly studied field in the pharmaceutical industry and cancer research. Organocatalyst terminally functionalized dendrimers present the possibility of both catalytic utility and increased recovery in MacMillan-type asymmetric reactions. Terminal sites of generations 2.0, 3.0, and 4.0 PAMAM dendrimers have been functionalized with the MacMillan group's (2S, 5S)-5-benzyl-2-tert-butyl-3-methylimidazolidin-4-one catalyst. These functionalized PAMAM dendrimers were characterized by NMR and MALDITOF MS analysis. The organocatalyst functionalized dendrimers show promising yield, enantioselectivity, and recoverability in MacMillan-type organocatalytic reactions.
Flynn, Autumn R., "The Synthesis of Dendrimer-Bound Catalysts and Their Use in MacMillan-Type Reactions" (2015). Honors Theses, 1963-2015. 61.