Interdependence of vascular and neural stem cells: relationship to neurological disorders
Scientists think there may be a molecular link between brain and blood vessel development as the two systems form along similar timelines during embryonic development. The possible interconnection of the neural and vascular environments could play an important role in both developing and adult brains, elucidating the mechanisms in developmental disorders, such as Down syndrome, and also have a role in brain recovery from stroke and the onset of Alzheimer’s disease. This study examines results from this phase of the project, which is to ensure the cell populations being used, particularly the vascular cells, are expressing appropriate markers when grown in culture. This forum will cover the background and then explain how the vascular populations used are appropriate. It will continue to elaborate on the comparison of other factors expressed by vascular cells and will also look at future research directions, which will assess additional cell-type specific markers at the gene expression level and at the protein level. If there is an interdependence between the vascular and neural environments, differences in the vascular microenvironment could have an impact on neural development and adult neural stability and repair. This could affect the development of new therapeutics and testing assays at the intersection of basic and translational research as well as on the understanding of neural diseases overall.
Doze, Valerie N., "Interdependence of vascular and neural stem cells: relationship to neurological disorders" (2018). Forum Lectures. 380.