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Biology | Cell and Developmental Biology | Life Sciences | Medical Cell Biology | Medical Sciences | Medicine and Health Sciences


Stephen Saupe, Biology


Heart Disease is the number one cause of death in the United States and affects many individuals on a daily basis. The purpose of this research was to explore possible tissue regeneration therapies that aim to improve and recover function of damaged myocardial tissue commonly seen as a side-effect of chronic heart disease. Cardiac tissue engineering using induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) is a relatively new method that involves dedifferentiating cells from any tissue of the host into pluripotent stem cells. These cells are then guided to be differentiated into functioning myocardial cells that can be used to repair damaged tissue and restore cardiac function to affected areas. The process and effectiveness of iPSC-CMs as a treatment will be discussed.