Recent insights on DNA repair: the mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes

Document Type


Publication Date



Biology | Molecular Genetics


Recent years have witnessed remarkable progress in the investigative field that embraces how living cells respond to genomic injury. This progress is evidenced by insights about the detailed mechanisms of various DNA repair and damage tolerance mechanisms, the structure of several components of DNA repair "machines," the extent of the evolutionary conservation of DNA repair in eukaryotes, and the emerging relationship between DNA repair and other cellular events that impact on genomic fidelity and integrity. These proceedings contain numerous contributions that address several of these advances in considerable detail. My own comments will focus on recent new insights that derive from the study of nucleotide excision repair (NER) in the yeast Saccharomyces cerevisiae, with a particular emphasis on selected mechanistic considerations and the relationship between DNA repair and other cellular processes.