Celebrating Scholarship and Creativity Day (2018-)
Document Type
Thesis
Publication Date
5-1-2026
Disciplines
Biology
Advisor
Jacob Pithan
Abstract
Extremophiles are organisms that can survive in extreme environmental conditions, and their unique biological adaptations have gained attention for potential applications in cancer research. This paper explores how the molecular characteristics of extremophiles, such as enhanced DNA repair, resistance to oxidative stress, and structural stability, may be useful in improving cancer treatment strategies. A range of studies were examined to understand both direct and indirect roles of extremophile-derived compounds in oncology. Some research shows that compounds from organisms like Deinococcus radiodurans and extremophilic Streptomyces species can inhibit cancer cell growth, increase reactive oxygen species, and trigger apoptosis. Other studies highlight how extremophiles contribute to the development of drug delivery systems, including nanoparticle-based methods that improve targeting and allow for more controlled release of chemotherapy drugs. In addition, extremophile-inspired mechanisms have been used to design new synthetic compounds and supportive therapies that may help reduce damage to healthy cells during treatment. While these findings are promising, there are still several limitations that need to be addressed. Much of the current research is based on in vitro experiments or early-stage animal models, which makes it difficult to fully understand how these approaches would work in human patients. There are also concerns about toxicity, immune responses, and the challenges of producing these compounds on a large scale. Overall, extremophiles provide a valuable perspective for developing new approaches to cancer treatment, especially to enhance existing therapies rather than replace them. Continued research will be necessary to better understand their safety, effectiveness, and potential for clinical use.
Recommended Citation
Malmgren, Jason, "Cancer Gets Extreme: How Extremophiles Can Improve Research and Therapy" (2026). Celebrating Scholarship and Creativity Day (2018-). 334.
https://digitalcommons.csbsju.edu/ur_cscday/334