Amino Acid Phosphoramidate Nucleosides: Potential ADEPT/GDEPT Substrates
Document Type
Article
Publication Date
11-2001
Disciplines
Chemistry | Physical Sciences and Mathematics
Abstract
A series of aromatic, serum-stable, water soluble and nontoxic amino acid phosphoramidate monoesters of 5-fluoro-2'-deoxyuridine (FUdR) and 1-beta-arabinofuranosylcytosine (Ara-C) was shown to inhibit the cellular growth of the human leukemia cell line CCRF-CEM in the presence of human prostatic acid phosphatase (hPAP).
Recommended Citation
McIntee, E.J.; Wagner, C.R. Amino Acid Phosphoramidate Nucleosides: Potential ADEPT/GDEPT Substrates. Bioorganic & Medicinal Chemistry Letters, 2001, 11, 2803-2805.