Title

Cyclization of 5-hexynoic acid to 3-alkoxy-2-cyclohexenones

Document Type

Article

Publication Date

2011

Abstract

The one-pot cyclization of 5-hexynoic acid to produce 3-alkoxy-2-cyclohexenones proceeds in good yields (58–90%). 3-Hexynoic acid was converted to its acyl chloride with the aid of oxalyl chloride and was cyclized to 3-chloro-2-cyclohexenone upon addition of indium(III) chloride. Subsequent addition of alcohol nucleophiles led to the desired 3-alkoxy-2-cyclohexenones.

Comments

DOI: 10.3762/bjoc.7.155