Title

Hypoiodite-Mediated Catalytic Cyclopropanation of Alkenes with Malononitrile

Document Type

Article

Publication Date

11-2014

Abstract

An efficient synthetic procedure for dicyano-cyclopropanation of alkenes using catalytic amounts of molecular iodine as a precatalyst and tert-butyl hydroperoxide (TBHP) as a terminal oxidant under mild conditions has been developed. This catalytic reaction works especially well for the aryl-substituted double bond affording products of cyclopropanation in high yields. A catalytic cycle based on the generated in situ hypoiodite species has been proposed.

Comments

DOI: 10.1002/adsc.201400627